Concurrent Sessions

Sunday, May 7, 2006, 15.00 - 16.30 hrs - Room N-N1-O-O1

C03. Neurogenetics

C16. Amisyn, SCAMP5, CLIC4 and NBEA are candidate genes for autism and suggest a role for neuron vesicle trafficking in the pathogenesis of autism.
D. Castermans¹, K. Freson², J. Vermeesch³, C. Schrander-Stumpel⁴, J. Fryns³, W. Van de Ven⁵, C. Van Geet², J. Steyaert^3,4, J. Creemers¹, K. Devriendt³;
¹Laboratory for Molecular Cell Biology, Department for Human Genetics, Leuven, Belgium, ²Center for Molecular and Vascular Biology, Department of Pathology, Leuven, Belgium, ³Division of Clinical Genetics, Center for Human Genetics, Leuven, Belgium, ⁴Center for Clinical Genetics, Maastricht, The Netherlands, ⁵Laboratory of Molecular Oncology, Department of Human Genetics, Leuven, Belgium.

C17. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy
A. Jordanova^1,2, J. Irobi², F. P. Thomas³, P. Van Dijck⁴, K. Meerschaert⁵, M. Dewil⁶, I. Dierick², A. Jacobs², E. De Vriendt², V. Guergueltcheva¹, C. V. Rao³, I. Tournev¹, F. A. Gondim³, M. D’Hooghe⁷, V. Van Gerwen², P. Callaerts⁸, L. Van Den Bosch⁶, J. P. Timmermans⁹, W. Robberecht⁶, J. Gettemans⁵, J. M. Thevelein¹⁰, P. De Jonghe², I. Kremensky¹, V. Timmerman²;
¹Sofia Medical University, Sofia, Bulgaria, ²Molecular Genetics Department (VIB8), Antwerpen, Belgium, ³Saint Louis University, Saint Louis, MA, United States, ⁴Department of Molecular Microbiology and Immunology (VIB10), Leuven, Belgium, ⁵Department of Medical Protein Research (VIB9), Gent, Belgium, ⁶Department of Experimental Neurology, Leuven, Belgium, ⁷Sint-Jan Hospital, Brugge, Belgium, ⁸Laboratory of Developmental Genetics (VIB-PRJ8), Leuven, Belgium, ⁹University of Antwerp, Antwerpen, Belgium, ¹⁰Department of Molecular Microbiology (VIB10), Leuven, Belgium.

C18. Distinguishing neurodegenerative disorders with tau pathology using mRNA expression microarrays
I. F. Bronner^1,2, Z. Bochdanovits^1,2, P. Rizzu^1,2, J. C. van Swieten³, R. Ravid⁴, W. Kamphorst⁵, P. Heutink^1,2;
¹VU University Medical Center, Department of Human genetics, Section Medical Genomics, Amsterdam, The Netherlands, ²Center for Neurogenomics and Cognitive Research, VU University Medical Center and VU University, Amsterdam, The Netherlands, ³Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands, ⁴The Netherlands Brain Bank, Amsterdam, The Netherlands, ⁵Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.

C19. A mutation in the nup62 gene causes Infantile Bilateral Striatal Necrosis
L. Basel-Vanagaite^1,2, L. Muncher², R. Straussberg^3,2, M. Pasmanik-Chor⁴, M. Yahav², L. Rainshtein⁵, C. A. Walsh⁶, N. Magal^2,5, E. Taub⁷, V. Drasinover⁵, G. Rechavi⁸, A. J. Simon⁸, M. Shohat^7,2;
¹Schneider Children's Medical Center of Israel and Rabin Medical Center, Petah Tikva, Israel, ²Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Schneider Children's Medical Center of Israel, Petah Tikva, Israel, ⁴Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel, ⁵Felsenstein Medical Research Center, Petah Tikva, Israel, ⁶Harvard Medical School, Boston, MA, United States, ⁷Rabin Medical Center, Petah Tikva, Israel, ⁸The Chaim Sheba Medical Center, Tel Hashomer, Israel.

C20. Impaired ganglioside synthesis involved with pathogenic mechanism in a familial form of multiple sclerosis
E. Vitale^1,2, C. Yildirim – Toruner¹, S. Husain¹, G. Toruner¹, M. Schwalb¹, S. Cook¹;
¹UMDNJ New Jersey Medical School, Newark, NJ, United States, ²CNR Institute of Cybernetics, Pozzuoli (NA), Italy.

C21. Transcriptional deregulation by the mutant Huntington Disease (HD) protein: implications for pathogenesis
S. Y. Cong^1,2, B. A. Pepers^1,3, R. A. C. Roos³, G. J. B. van Ommen^1,4, J. C. Dorsman^1,4,5;
¹Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands, ²Department of Neurology, The second affiliated hospital of China Medical University, Shenyang, China, ³Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands, ⁴Center for Medical System Biology, Leiden/Amsterdam/Rotterdam, The Netherlands, ⁵VU University Medical Center, Amsterdam, The Netherlands.